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Immunohistochemical expression of estrogen and progesterone receptors and outcomes in patients with newly diagnosed uterine leiomyosarcoma.
- Source :
-
Gynecologic oncology [Gynecol Oncol] 2012 Mar; Vol. 124 (3), pp. 558-62. Date of Electronic Publication: 2011 Nov 13. - Publication Year :
- 2012
-
Abstract
- Objective: We assessed the IHC expression of ER and PR and their prognostic significance in uterine leiomyosarcoma (LMS).<br />Methods: We identified 43 "high-grade" uterine LMS cases from 7/82-7/07 for whom ER/PR IHC analysis was performed at initial diagnosis at our institution.<br />Results: Disease was confined to the uterine body in 20/43 (47%). Eighteen (42%) of 43 were ER(+); 17/42 (41%) were PR(+). At last follow-up, 33 (77%) had recurred or progressed, and 23 (54%) had died. PR expression was associated with improved progression-free survival (PFS; P=0.002) and overall survival (OS; P=0.03) overall; ER expression was not. After adjusting for stage, ER expression was associated with PFS (P=0.01), not OS (P=0.3), and PR expression maintained a significant association with PFS (P=0.002) and approached a significant association with OS (P=0.05). Neither ER nor PR expression was associated with outcome in cases with disease outside the uterine body. In cases with confined disease, median PFS for ER(+) or PR(+) cases was not reached compared to 16.9 months for ER(-) cases (95% CI: 8.1-25.7; P=0.03) and 13.5 months for PR(-) cases (95% CI: 5.9-21.1; P=0.001). Only 1/10 PR(+) cases recurred and died; 9/10 PR(-) cases recurred, and 5 died. Two of 9 ER(+) cases recurred and died; 8/11 ER(-) cases recurred, and 4 died.<br />Conclusion: ER/PR expression is associated with survival outcomes in patients with high-grade uterine LMS confined to the uterine body. PR expression seems capable of identifying cases confined to the uterine body, which have better outcomes.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Cohort Studies
Disease-Free Survival
Female
Humans
Immunohistochemistry
Leiomyosarcoma pathology
Leiomyosarcoma surgery
Middle Aged
Neoplasm Grading
Neoplasm Staging
Survival Rate
Treatment Outcome
Uterine Neoplasms pathology
Uterine Neoplasms surgery
Leiomyosarcoma metabolism
Receptors, Estrogen biosynthesis
Receptors, Progesterone biosynthesis
Uterine Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1095-6859
- Volume :
- 124
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Gynecologic oncology
- Publication Type :
- Academic Journal
- Accession number :
- 22085894
- Full Text :
- https://doi.org/10.1016/j.ygyno.2011.11.009