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European Vaccine Initiative: lessons from developing malaria vaccines.
- Source :
-
Expert review of vaccines [Expert Rev Vaccines] 2011 Dec; Vol. 10 (12), pp. 1697-708. - Publication Year :
- 2011
-
Abstract
- For over 10 years, the European Vaccine Initiative (EVI; European Malaria Vaccine Initiative until 2009) has contributed to the development of 24 malaria candidate vaccine antigens with 13 vaccine candidates being advanced into Phase I clinical trials, two of which have been transitioned for further clinical development in sub-Saharan Africa. Since its inception the EVI organization has operated as a funding agency, but with a clear service-oriented strategy. The scientific successes and difficulties encountered during these years and how these efforts have led to standardization and harmonization in vaccine development through large-scale European consortia are discussed. In the future, the EVI will remain instrumental in the pharmaceutical and clinical development of vaccines against 'diseases of poverty' with a continued focus on malaria. EVI will continue to focus on funding and managing preclinical evaluation up to Phase I/II clinical trials and strengthening the vaccine-development infrastructure in Europe, albeit with a global orientation.
- Subjects :
- Adjuvants, Immunologic standards
Antigens, Viral immunology
Clinical Trials as Topic
Europe
Humans
Immunization Programs economics
Immunization Programs organization & administration
International Cooperation
Malaria immunology
Malaria virology
Malaria Vaccines immunology
Malaria Vaccines standards
Translational Research, Biomedical organization & administration
Vaccines, Subunit immunology
Malaria prevention & control
Malaria Vaccines economics
Translational Research, Biomedical economics
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8395
- Volume :
- 10
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Expert review of vaccines
- Publication Type :
- Academic Journal
- Accession number :
- 22085173
- Full Text :
- https://doi.org/10.1586/erv.11.158