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Gram-scale synthesis of the A'B'-subunit of angelmicin B.

Authors :
Milgram BC
Liau BB
Shair MD
Source :
Organic letters [Org Lett] 2011 Dec 16; Vol. 13 (24), pp. 6436-9. Date of Electronic Publication: 2011 Nov 15.
Publication Year :
2011

Abstract

A gram-scale enantiospecific synthesis of the A'B'-subunit of angelmicin B is reported. The synthesis involves a Lewis acid catalyzed contrasteric Diels-Alder reaction and a tandem silyl zincate 1,6-addition/enolate oxidation sequence.

Details

Language :
English
ISSN :
1523-7052
Volume :
13
Issue :
24
Database :
MEDLINE
Journal :
Organic letters
Publication Type :
Academic Journal
Accession number :
22084899
Full Text :
https://doi.org/10.1021/ol202728v