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Co-morbidities associated with tuberculosis in an autopsy case series.

Authors :
Sbrana E
Grise J
Stout C
Aronson J
Source :
Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2011 Dec; Vol. 91 Suppl 1, pp. S38-42. Date of Electronic Publication: 2011 Nov 13.
Publication Year :
2011

Abstract

A retrospective review of cases of tuberculosis examined by our Autopsy Division was undertaken to determine the most common associated co-morbidities. Forty-six cases of tuberculosis were examined between 2000 and 2010. The subpopulation of decedents studied included a large number of incarcerated individuals and showed an age distribution from 30 to 78 years. Thirty-five of the cases reviewed showed one or more co-morbidities, primarily viral hepatitis C, cancer, human immunodeficiency virus (HIV), cardiovascular diseases, and chronic obstructive pulmonary diseases. Almost 30% of the cases showed evidence of extrapulmonary disease, including one case of tuberculous meningitis. In approximately 20% of the cases, rapid progressive or disseminated tuberculosis was identified as immediate cause of death. Tuberculosis was the immediate cause of death in 20% of the hepatitis C-infected group and in 14% of the decedents diagnosed with cancer, compared to over 45% of the HIV-infected decedents. This observation is consistent with previous studies reporting an enhanced mortality from tuberculosis in HIV-infected subjects. Interestingly, rapid progressive tuberculosis was identified as immediate cause of death in two cases with no associated co-morbidities; both decedents were young immunocompetent adults, suggesting an increasing susceptibility of this subpopulation to tuberculosis exposure and to severe disease.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1873-281X
Volume :
91 Suppl 1
Database :
MEDLINE
Journal :
Tuberculosis (Edinburgh, Scotland)
Publication Type :
Academic Journal
Accession number :
22082616
Full Text :
https://doi.org/10.1016/j.tube.2011.10.008