Emergence in Japan of an imipenem-susceptible, meropenem-resistant Klebsiella pneumoniae carrying blaIMP-6.

Authors :: Shigemoto N
Kuwahara R
Kayama S
Shimizu W
Onodera M
Yokozaki M
Hisatsune J
Kato F
Ohge H
Sugai M
Source :: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2012 Jan; Vol. 72 (1), pp. 109-12. Date of Electronic Publication: 2011 Nov 10.
Publication Year :: 2012
Abstract: We identified 5 Klebsiella pneumoniae isolates showing high resistance to β-lactams except imipenem and designated them ISMRK (imipenem-susceptible but meropenem-resistant Klebsiella). They carried the bla(IMP-6) and bla(CTX-M-2) on a self-transmissible plasmid. ISMRK may be falsely categorized as susceptible to carbapenems if imipenem is used to screen carbapenem resistance.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)

Subjects :: Aged, 80 and over
Conjugation, Genetic
Female
Gene Transfer, Horizontal
Humans
Japan
Klebsiella pneumoniae drug effects
Klebsiella pneumoniae genetics
Klebsiella pneumoniae isolation & purification
Male
Meropenem
Plasmids analysis
Anti-Bacterial Agents pharmacology
Imipenem pharmacology
Klebsiella Infections microbiology
Klebsiella pneumoniae enzymology
Thienamycins pharmacology
beta-Lactam Resistance
beta-Lactamases metabolism

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