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Aortic stiffness predicts functional outcome in patients after ischemic stroke.
- Source :
-
Stroke [Stroke] 2012 Feb; Vol. 43 (2), pp. 543-4. Date of Electronic Publication: 2011 Nov 10. - Publication Year :
- 2012
-
Abstract
- Background and Purpose: Increased aortic stiffness (measured by carotid-femoral pulse wave velocity) and central augmentation index have been shown to independently predict cardiovascular events, including stroke. We studied whether pulse wave velocity and central augmentation index predict functional outcome after ischemic stroke.<br />Methods: In a prospective study, we enrolled 99 patients with acute ischemic stroke (age 63.7 ± 12.4 years, admission National Institutes of Health Stroke Scale score 6.6 ± 6.6, mean ± SD). Carotid-femoral pulse wave velocity and central augmentation index (SphygmoCor) were measured 1 week after stroke onset. Functional outcome was evaluated 90 days after stroke using the modified Rankin Scale with modified Rankin Scale score of 0 to 1 considered an excellent outcome.<br />Results: In univariate analysis, low carotid-femoral pulse wave velocity (P=0.000001) and low central augmentation index (P=0.028) were significantly associated with excellent stroke outcome. Age, severity of stroke, presence of previous stroke, diabetes, heart rate, and peripheral pressures also predicted stroke functional outcome. In multivariate analysis, the predictive value of carotid-femoral pulse wave velocity (<9.4 m/s) remained significant (OR, 0.21; 95% CI, 0.06-0.79; P=0.02) after adjustment for age, National Institutes of Health Stroke Scale score on admission, and presence of previous stroke. By contrast, central augmentation index had no significant predictive value after adjustment.<br />Conclusions: This study indicates that aortic stiffness is an independent predictor of functional outcome in patients with acute ischemic stroke.
- Subjects :
- Aged
Aorta
Brain Ischemia complications
Brain Ischemia rehabilitation
Carotid Arteries physiology
Female
Femoral Artery physiology
Hemodynamics physiology
Humans
Logistic Models
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Risk Factors
Stroke etiology
Stroke Rehabilitation
Blood Flow Velocity physiology
Brain Ischemia therapy
Stroke therapy
Vascular Stiffness physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4628
- Volume :
- 43
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Stroke
- Publication Type :
- Academic Journal
- Accession number :
- 22076001
- Full Text :
- https://doi.org/10.1161/STROKEAHA.111.633487