Back to Search
Start Over
AIP56: a novel bacterial apoptogenic toxin.
- Source :
-
Toxins [Toxins (Basel)] 2010 Apr; Vol. 2 (4), pp. 905-18. Date of Electronic Publication: 2010 Apr 26. - Publication Year :
- 2010
-
Abstract
- Photobacterium damselae subsp. piscicida (Phdp) is a Gram-negative pathogen agent of an important fish septicemia. The key virulence factor of Phdp is the plasmid-encoded exotoxin AIP56, which is secreted by exponentially growing pathogenic strains. AIP56 has 520 amino acids including an N-terminal cleavable signal peptide of 23 amino acid residues, two cysteine residues and a zinc-binding region signature HEXXH that is typical of most zinc metallopeptidases. AIP56 induces in vitro and in vivo selective apoptosis of fish macrophages and neutrophils through a caspase-3 dependent mechanism that also involves caspase-8 and -9. In vivo, the AIP56-induced phagocyte apoptosis progresses to secondary necrosis with release of cytotoxic phagocyte molecules including neutrophil elastase. Fish injected with recombinant AIP56 die with a pathology similar to that seen in the natural infection.
Details
- Language :
- English
- ISSN :
- 2072-6651
- Volume :
- 2
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Toxins
- Publication Type :
- Academic Journal
- Accession number :
- 22069616
- Full Text :
- https://doi.org/10.3390/toxins2040905