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Functional analysis of a putative Dothistromin toxin MFS transporter gene.
- Source :
-
Toxins [Toxins (Basel)] 2009 Dec; Vol. 1 (2), pp. 173-87. Date of Electronic Publication: 2009 Dec 08. - Publication Year :
- 2009
-
Abstract
- Dothistromin is a non-host selective toxin produced by the pine needle pathogen Dothistroma septosporum. Dothistromin is not required for pathogenicity, but may have a role in competition and niche protection. To determine how D. septosporum tolerates its own toxin, a putative dothistromin transporter, dotC, was investigated. Studies with mutants lacking a functional dotC gene, overproducing dotC, or with a dotC-GFP fusion gene, did not provide conclusive evidence of a role in dothistromin efflux. The mutants revealed a major effect of dotC on dothistromin biosynthesis but were resistant to exogenous dothistromin. Intracellular localization studies suggest that compartmentalization may be important for dothistromin tolerance.
- Subjects :
- Ascomycota genetics
Pinus
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6651
- Volume :
- 1
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Toxins
- Publication Type :
- Academic Journal
- Accession number :
- 22069539
- Full Text :
- https://doi.org/10.3390/toxins1020173