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Critical factors in the development of tumor-targeted anti-inflammatory nanomedicines.
- Source :
-
Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2012 Jun 10; Vol. 160 (2), pp. 232-8. Date of Electronic Publication: 2011 Oct 25. - Publication Year :
- 2012
-
Abstract
- Tumors are complex and dynamic assemblies of different cell types within an atypical/abnormal architecture. Tumor-associated macrophages, mast cells, dendritic cells, eosinophils, fibroblasts are present in and around tumors and contribute to an abundant, deregulated and long lasting chronic inflammation, a permissive microenvironment for tumor proliferation. The fact that tumor-initiated inflammation overrides protective immunity and supports tumor development, combined with the successful strategy of liposomal drug targeting to tumor tissues, gave rise to a novel attractive antitumor therapeutic strategy: targeting anti-inflammatory drugs to tumors. As many natural bioactive compounds have anti-inflammatory properties and act by targeting multiple signaling pathways, their medicinal application involves the treatment of cancer. The nanoformulation into liposomes circumvents solubility, stability, bioavailability issues associated with these compounds, while promoting tumor drug accumulation. Liposomal formulations of resveratrol, carvacrol phosphate, pterostilbene phosphate, N-(3-oxo-dodecanoyl)-l-Homoserine lactone, caffeic acid and caffeic acid phenethyl ester (CAPE) were prepared and characterized. In vivo, B16F10 melanoma bearing mice seem not to be responsive to liposomal treatments of natural compounds. The specific combination of tumor model, drug delivery system and drug potency are crucial factors that should be considered in the development and evaluation of new nanomedicines for cancer-inflammation therapy, especially when translating from preclinical models.<br /> (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Anti-Inflammatory Agents, Non-Steroidal chemistry
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Antineoplastic Agents chemistry
Antineoplastic Agents therapeutic use
Drug Compounding
Drug Screening Assays, Antitumor
Liposomes
Male
Melanoma, Experimental immunology
Melanoma, Experimental pathology
Mice
Mice, Inbred C57BL
Molecular Structure
Neoplasm Transplantation
Treatment Outcome
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Antineoplastic Agents administration & dosage
Drug Carriers chemistry
Melanoma, Experimental drug therapy
Nanostructures chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4995
- Volume :
- 160
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of controlled release : official journal of the Controlled Release Society
- Publication Type :
- Academic Journal
- Accession number :
- 22062692
- Full Text :
- https://doi.org/10.1016/j.jconrel.2011.10.019