Catalytic asymmetric diastereodivergent deracemization.

Authors :: Luparia M
Oliveira MT
Audisio D
Frébault F
Goddard R
Maulide N
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2011 Dec 23; Vol. 50 (52), pp. 12631-5. Date of Electronic Publication: 2011 Nov 04.
Publication Year :: 2011
Abstract: Your wish is my command: Deracemization is a powerful strategy wherein a racemate is converted into a 100 % yield of a single enantiopure product. A new concept in catalytic deracemization is presented, in which a racemate with n stereogenic elements can be selectively converted into each one of 2(m) (m = number of chiral centers of the product) different enantiopure products, by simple tuning of the reaction conditions.<br /> (Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)