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Diversity-oriented optical imaging probe development.
- Source :
-
Current opinion in chemical biology [Curr Opin Chem Biol] 2011 Dec; Vol. 15 (6), pp. 760-7. Date of Electronic Publication: 2011 Nov 04. - Publication Year :
- 2011
-
Abstract
- The development of optical probes is receiving considerable attention due to their rising adaptation in diagnostics and medical imaging. Diversity-oriented approaches make use of combinatorial chemistry and high-throughput screenings to enrich the spectral and structural variety of these probes and effectively identify those with specific properties (e.g. molecular affinity, cellular selectivity, high photostability, and sensitivity). Herein we review recent examples in which diversity-driven strategies have assisted the discovery of new molecular imaging probes.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Subjects :
- Combinatorial Chemistry Techniques
Fluorescent Dyes analysis
Fluorescent Dyes metabolism
Green Fluorescent Proteins analysis
High-Throughput Screening Assays
Molecular Probes analysis
Molecular Probes metabolism
Fluorescent Dyes chemical synthesis
Molecular Imaging methods
Molecular Probes chemical synthesis
Staining and Labeling methods
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0402
- Volume :
- 15
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Current opinion in chemical biology
- Publication Type :
- Academic Journal
- Accession number :
- 22055497
- Full Text :
- https://doi.org/10.1016/j.cbpa.2011.10.007