Synthesis and in vitro characterization of semitelechelic poly[N-(2-hydroxypropyl)methacrylamide]-trastuzumab conjugates targeted to breast cancer.

Authors :: Lee JH
Sabnis G
Nan A
Source :: Macromolecular bioscience [Macromol Biosci] 2012 Jan; Vol. 12 (1), pp. 55-60. Date of Electronic Publication: 2011 Aug 25.
Publication Year :: 2012
Abstract: Trastuzumab (TRZ) is a humanized monoclonal antibody that targets the extracellular domain of the human epidermal growth factor receptor type 2 (Her2). Semitelechelic (ST) poly[N-(2-hydroxypropyl)methacrylamide]-TRZ conjugates are successfully synthesized and evaluated as a potential drug delivery system that actively targets Her2-overexpressing cancer cells. The ST backbone shows favorable characteristics when conjugated to TRZ. The conjugate exhibits comparable and prolonged anticancer activity when compared to free TRZ in Her2 overexpressing breast cancer cell lines.<br /> (Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Antibodies, Monoclonal, Humanized chemistry
Antineoplastic Agents chemistry
Breast Neoplasms pathology
Cell Survival
Female
Humans
Mitogen-Activated Protein Kinases metabolism
Polymethacrylic Acids chemistry
Receptor, ErbB-2 metabolism
Trastuzumab
Tumor Cells, Cultured
Antibodies, Monoclonal, Humanized administration & dosage
Antineoplastic Agents administration & dosage
Antineoplastic Agents chemical synthesis
Breast Neoplasms drug therapy
Drug Delivery Systems methods
Polymethacrylic Acids administration & dosage
Polymethacrylic Acids chemical synthesis

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