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Tumor and breast volume ratio as a predictive factor for axillary lymph node metastases in T1c ductal invasive breast cancer: prospective observational clinico-pathological study.
- Source :
-
Japanese journal of clinical oncology [Jpn J Clin Oncol] 2011 Dec; Vol. 41 (12), pp. 1322-6. Date of Electronic Publication: 2011 Oct 27. - Publication Year :
- 2011
-
Abstract
- Objective: The status of the axilla is the single most important prognostic indicator of overall survival in patients with breast cancer. Sentinel-node biopsy has false-negative rates of 5-10%. The aim of this study was to assess the importance of tumor and breast volume ratio as a predictive factor for axillary lymph node metastases in patients with T1c ductal invasive breast cancer.<br />Methods: This study included 136 consecutive patients with T1c ductal invasive breast cancer. Three tumor diameters were measured. Tumor volume was calculated by the formula for ellipse. Breast volume was measured preoperatively. Tumor and breast volume ratio was calculated and shown per thousand.<br />Results: Tumor and breast volume ratio is a new independent predictive factor for axillary lymph node metastase in T1c ductal invasive breast cancer.<br />Conclusions: This predictive factor could help to define a subgroup of patients who will be at a higher risk for axillary lymph node metastase and would benefit from additional close follow up or axillary lymph node dissection.
- Subjects :
- Adult
Aged
Aged, 80 and over
Axilla
False Negative Reactions
Female
Humans
Lymphatic Metastasis pathology
Middle Aged
Multivariate Analysis
Neoplasm Staging
Patient Selection
Proportional Hazards Models
Prospective Studies
Sensitivity and Specificity
Sentinel Lymph Node Biopsy
Taiwan
Breast Neoplasms pathology
Carcinoma, Ductal, Breast pathology
Lymph Node Excision
Tumor Burden
Subjects
Details
- Language :
- English
- ISSN :
- 1465-3621
- Volume :
- 41
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Japanese journal of clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 22039579
- Full Text :
- https://doi.org/10.1093/jjco/hyr149