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A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3.
- Source :
-
Nature immunology [Nat Immunol] 2011 Oct 30; Vol. 12 (12), pp. 1194-201. Date of Electronic Publication: 2011 Oct 30. - Publication Year :
- 2011
-
Abstract
- The acquisition of pathogen-derived antigen by dendritic cells (DCs) is a key event in the generation of cytotoxic CD8(+) T cell responses. In mice, the intracellular bacterium Listeria monocytogenes is directed from the blood to splenic CD8α(+) DCs. We report that L. monocytogenes rapidly associated with platelets in the bloodstream in a manner dependent on GPIb and complement C3. Platelet association targeted a small but immunologically important portion of L. monocytogenes to splenic CD8α(+) DCs, diverting bacteria from swift clearance by other, less immunogenic phagocytes. Thus, an effective balance is established between maintaining sterility of the circulation and induction of antibacterial immunity by DCs. Other gram-positive bacteria also were rapidly tagged by platelets, revealing a broadly active shuttling mechanism for systemic bacteria.
- Subjects :
- Animals
Blood Platelets metabolism
CD8-Positive T-Lymphocytes immunology
Dendritic Cells metabolism
Dendritic Cells microbiology
Listeriosis immunology
Listeriosis microbiology
Mice
Mice, Inbred C57BL
Mice, Knockout
Platelet Aggregation immunology
Spleen immunology
Spleen microbiology
Blood Platelets microbiology
CD8 Antigens metabolism
Complement C3 metabolism
Dendritic Cells immunology
Listeria monocytogenes immunology
Platelet Glycoprotein GPIb-IX Complex metabolism
Platelet Membrane Glycoproteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2916
- Volume :
- 12
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 22037602
- Full Text :
- https://doi.org/10.1038/ni.2140