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Two-way calf to dam major histocompatibility class I compatibility increases risk for retained placenta in cattle.
- Source :
-
American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2012 Mar; Vol. 67 (3), pp. 224-30. Date of Electronic Publication: 2011 Oct 30. - Publication Year :
- 2012
-
Abstract
- Problem: In cattle, retained placenta (RP) is suggested to arise from failure of immune-mediated rejection of the fetal membranes by the maternal immune system and is associated with major histocompatibility (MHC) class I compatibility between calf and dam.<br />Method of Study: To study the association between RP and different MHC class I compatibilities between calf-dam-granddam combinations, massively parallel pyrosequencing was used to determine the MHC class I haplotypes of cows with and without RP.<br />Results: Two-way calf to dam MHC class I compatibility gave a high risk for RP. There was a tendency for a higher risk for RP with calf to dam MHC class I compatibility.<br />Conclusions: We concluded that in two-way compatible pregnancies, the maternal immune system fails to reject the fetal membranes, and the fetal immune system does not mount an immune response against maternal MHC class I antigens that could influence the immune-mediated rejection of the fetal membranes by the maternal immune system. The lack of immune-mediated rejection of the fetal membranes by the maternal immune system increases the risk of occurrence of RP.<br /> (© 2011 John Wiley & Sons A/S.)
Details
- Language :
- English
- ISSN :
- 1600-0897
- Volume :
- 67
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of reproductive immunology (New York, N.Y. : 1989)
- Publication Type :
- Academic Journal
- Accession number :
- 22035222
- Full Text :
- https://doi.org/10.1111/j.1600-0897.2011.01085.x