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Outcome of Graves' orbitopathy after total thyroid ablation and glucocorticoid treatment: follow-up of a randomized clinical trial.
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2012 Jan; Vol. 97 (1), pp. E44-8. Date of Electronic Publication: 2011 Oct 26. - Publication Year :
- 2012
-
Abstract
- Context: In a previous study, we found that total thyroid ablation (thyroidectomy plus (131)I) is associated with a better outcome of Graves' orbitopathy (GO) compared with thyroidectomy alone, as observed shortly (9 months) after glucocorticoid (GC) treatment.<br />Objective: The objective of the study was to evaluate the outcome of GO in the same patients of the previous study over a longer period of time.<br />Design: This was a follow-up of a randomized study.<br />Setting: The study was conducted at a referral center.<br />Patients: Fifty-two of 60 original patients with mild to moderate GO participated in the study.<br />Interventions: Patients randomized into thyroidectomy (TX) or total thyroid ablation and treated with GC were reevaluated in 2010, namely 88.0 ± 17.7 months after GC, having undergone an ophthalmological follow-up in the intermediate period.<br />Main Outcome Measures: The main outcome measures included the following: 1) GO outcome; 2) time to GO best possible outcome and to GO improvement; and 3) additional treatments.<br />Results: GO outcome at the end of the follow-up was similar in the two groups. However, the time required for the best possible outcome to be achieved was longer in the TX group (24 vs. 3 months, P = 0.0436), as was the time required for GO to improve (60 vs. 3 months, P = 0.0344). Additional treatments were given to a similar proportion of patients in each group (TX, 28%, total thyroid ablation, 25.9%), but they affected GO beneficially more often in the TX group (28 vs. 3.7%, P: 0.0412).<br />Conclusions: Compared with thyroidectomy alone, total thyroid ablation allows the achievement of the best possible outcome and an improvement of GO within a shorter period of time.
- Subjects :
- Adult
Female
Follow-Up Studies
Graves Ophthalmopathy diagnosis
Humans
Immunoglobulins, Thyroid-Stimulating blood
Male
Middle Aged
Prognosis
Quality of Life
Remission Induction
Time Factors
Treatment Outcome
Glucocorticoids therapeutic use
Graves Ophthalmopathy drug therapy
Graves Ophthalmopathy surgery
Thyroidectomy methods
Thyroidectomy rehabilitation
Subjects
Details
- Language :
- English
- ISSN :
- 1945-7197
- Volume :
- 97
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 22031515
- Full Text :
- https://doi.org/10.1210/jc.2011-2077