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Mitochondrial complex I and cell death: a semi-automatic shotgun model.
- Source :
-
Cell death & disease [Cell Death Dis] 2011 Oct 27; Vol. 2, pp. e222. Date of Electronic Publication: 2011 Oct 27. - Publication Year :
- 2011
-
Abstract
- Mitochondrial dysfunction often leads to cell death and disease. We can now draw correlations between the dysfunction of one of the most important mitochondrial enzymes, NADH:ubiquinone reductase or complex I, and its structural organization thanks to the recent advances in the X-ray structure of its bacterial homologs. The new structural information on bacterial complex I provide essential clues to finally understand how complex I may work. However, the same information remains difficult to interpret for many scientists working on mitochondrial complex I from different angles, especially in the field of cell death. Here, we present a novel way of interpreting the bacterial structural information in accessible terms. On the basis of the analogy to semi-automatic shotguns, we propose a novel functional model that incorporates recent structural information with previous evidence derived from studies on mitochondrial diseases, as well as functional bioenergetics.
Details
- Language :
- English
- ISSN :
- 2041-4889
- Volume :
- 2
- Database :
- MEDLINE
- Journal :
- Cell death & disease
- Publication Type :
- Academic Journal
- Accession number :
- 22030538
- Full Text :
- https://doi.org/10.1038/cddis.2011.107