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Chemokine and chemokine receptor gene polymorphism in Tunisian hemodialysis patients with HCV infection.
- Source :
-
Arab journal of nephrology and transplantation [Arab J Nephrol Transplant] 2011 Sep; Vol. 4 (3), pp. 117-24. - Publication Year :
- 2011
-
Abstract
- Introduction: Our aim was to investigate the possibility of a significant relationship between chemokines and chemokine receptor genes polymorphisms and the spontaneous clearance or the persistence of HCV infection.<br />Methods: A total of 96 hemodialysis (HD) patients infected with HCV were classified into two groups: G1 included 73 patients with persistently positive HCV-RNA and G2 included 23 HD patients who have spontaneously eliminated the virus. The control group consisted of 170 healthy blood donors. All subjects were genotyped for CCR5 ?32, CCR5 (-59029) A/G, CCR2 (64Ile) and MCP-1(-2518) A/G gene polymorphisms.<br />Results: Our results showed a statistically significant increased frequencies of the CCR2 (64Ile) and the (-59029) CCR5 A alleles in patients infected with HCV (22.1% and 35.9%) compared to G1 (24.3% and 40.6%) and compared to controls (14.4% and 20%). We also observed a lower frequency of the MCP-1 G allele and a greater frequency of the CCR5?32 variant in G2 (15.2% and 6.5%) compared to G1 (22.6% and 1.4%) that was not statistically significant. However, adjustment for known covariates (age, gender and HCV genotypes) didn't confirm the results of univariate analysis.<br />Conclusion: In conclusion, our study suggests a possible role for some of the studied chemokines polymorphisms in the spontaneous clearance or persistence of HCV infection in Tunisian population. These results should be further investigated by a prospective cohort studies and large population-based studies.
- Subjects :
- Adult
Aged
Alleles
Confidence Intervals
Female
Genotype
Hepatitis C, Chronic blood
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Polymorphism, Genetic
Renal Dialysis
Retrospective Studies
Tunisia
Chemokine CCL2 genetics
Hepacivirus
Hepatitis C, Chronic genetics
RNA, Viral blood
Receptors, CCR2 genetics
Receptors, CCR5 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1858-554X
- Volume :
- 4
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Arab journal of nephrology and transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 22026334
- Full Text :
- https://doi.org/10.4314/ajnt.v4i3.71023