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Multiple forms of lactoferrin in normal and leukemic human granulocytes.
- Source :
-
Experimental hematology [Exp Hematol] 1990 Sep; Vol. 18 (8), pp. 932-5. - Publication Year :
- 1990
-
Abstract
- Multiple forms of lactoferrin (Lf) were detected in granulocytes isolated from normal individuals and patients with granulocytic leukemias. One class of Lfs bound iron; a second class did not bind iron but possessed potent ribonuclease activity. The different forms of Lf were similar, if not identical, in their physical, chemical, and antigenic properties. The multiple forms of Lf may relate to the various functions ascribed to the molecule.
- Subjects :
- Blotting, Western
Electrophoresis, Polyacrylamide Gel
Enzyme-Linked Immunosorbent Assay
Humans
Iron metabolism
Lactoferrin metabolism
Milk, Human analysis
Molecular Weight
Peptide Fragments analysis
Peptide Hydrolases metabolism
Ribonucleases metabolism
Granulocytes analysis
Lactoferrin analysis
Lactoglobulins analysis
Leukemia, Myeloid blood
Subjects
Details
- Language :
- English
- ISSN :
- 0301-472X
- Volume :
- 18
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Experimental hematology
- Publication Type :
- Academic Journal
- Accession number :
- 2201556