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[Metabonomic phenotype of "formula corresponding to pattern types" based on "qi and yin deficiency pattern" of myocardial ischemia rat model].
- Source :
-
Yao xue xue bao = Acta pharmaceutica Sinica [Yao Xue Xue Bao] 2011 Aug; Vol. 46 (8), pp. 976-82. - Publication Year :
- 2011
-
Abstract
- In order to explore the scientific connotation of "Fangzhengduiying (formula corresponding to pattern types)", "Qiyinliangxuzheng (Qi and Yin deficiency pattern)" of myocardial ischemia rat model and GC-TOF/MS based metabonomic method were used for comparing the effects of Sheng-mai injection, Salvia injection and propranolol in the present study. After data processing and pattern recognition, Sheng-mai injection showed better efficacy than the other two drugs in accordance with not only visual observation from PLS-DA scores plots but also the number of abnormal endogenous compounds restored to the normal level. Further studies showed that Sheng-mai injection could normalize the level of plasma endothelin-1, the index related to cardiovascular diseases and sleep disorders, which verified the results of metabonomics. Finally, the regulated metabolites and related metabolic pathways were analyzed, and it was supposed that the effects of Sheng-mai injection involved in the alternation of energy metabolism, lipid metabolism, amino acids metabolism, and so on. These findings provided scientific evidence to Shengmai "Fang" used for "Qi and Yin deficiency pattern" correspondingly, indicating that metabonomics has great potential in traditional Chinese medical research, which provides a novel approach and way to modernization of traditional Chinese medicine.
- Subjects :
- Animals
Anti-Arrhythmia Agents pharmacology
Drug Combinations
Drugs, Chinese Herbal administration & dosage
Drugs, Chinese Herbal isolation & purification
Gas Chromatography-Mass Spectrometry methods
Injections
Male
Metabolomics methods
Myocardial Ischemia blood
Myocardial Ischemia pathology
Panax chemistry
Plants, Medicinal chemistry
Propranolol pharmacology
Rats
Rats, Sprague-Dawley
Salvia chemistry
Schisandraceae chemistry
Drugs, Chinese Herbal pharmacology
Endothelin-1 blood
Medicine, Chinese Traditional
Myocardial Ischemia metabolism
Qi
Yin Deficiency metabolism
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0513-4870
- Volume :
- 46
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Yao xue xue bao = Acta pharmaceutica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 22013615