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Lactation intensity and postpartum maternal glucose tolerance and insulin resistance in women with recent GDM: the SWIFT cohort.
- Source :
-
Diabetes care [Diabetes Care] 2012 Jan; Vol. 35 (1), pp. 50-6. Date of Electronic Publication: 2011 Oct 19. - Publication Year :
- 2012
-
Abstract
- Objective: To examine the association between breastfeeding intensity in relation to maternal blood glucose and insulin and glucose intolerance based on the postpartum 2-h 75-g oral glucose tolerance test (OGTT) results at 6-9 weeks after a pregnancy with gestational diabetes mellitus (GDM).<br />Research Design and Methods: We selected 522 participants enrolled into the Study of Women, Infant Feeding, and Type 2 Diabetes (SWIFT), a prospective observational cohort study of Kaiser Permanente Northern California members diagnosed with GDM using the 3-h 100-g OGTT by the Carpenter and Coustan criteria. Women were classified as normal, prediabetes, or diabetes according to American Diabetes Association criteria based on the postpartum 2-h 75-g OGTT results.<br />Results: Compared with exclusive or mostly formula feeding (>17 oz formula per 24 h), exclusive breastfeeding and mostly breastfeeding (≤6 oz formula per 24 h) groups, respectively, had lower adjusted mean (95% CI) group differences in fasting plasma glucose (mg/dL) of -4.3 (-7.4 to -1.3) and -5.0 (-8.5 to -1.4), in fasting insulin (μU/mL) of -6.3 (-10.1 to -2.4) and -7.5 (-11.9 to -3.0), and in 2-h insulin of -21.4 (-41.0 to -1.7) and -36.5 (-59.3 to -13.7) (all P < 0.05). Exclusive or mostly breastfeeding groups had lower prevalence of diabetes or prediabetes (P = 0.02).<br />Conclusions: Higher intensity of lactation was associated with improved fasting glucose and lower insulin levels at 6-9 weeks' postpartum. Lactation may have favorable effects on glucose metabolism and insulin sensitivity that may reduce diabetes risk after GDM pregnancy.
- Subjects :
- Adult
Blood Glucose metabolism
Bottle Feeding statistics & numerical data
California epidemiology
Cohort Studies
Diabetes Mellitus, Type 2 epidemiology
Female
Glucose Tolerance Test
Humans
Infant
Infant, Newborn
Insulin blood
Insulin physiology
Middle Aged
Pregnancy
Prevalence
Prospective Studies
Breast Feeding statistics & numerical data
Diabetes, Gestational physiopathology
Glucose Intolerance epidemiology
Insulin Resistance physiology
Lactation physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1935-5548
- Volume :
- 35
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Diabetes care
- Publication Type :
- Academic Journal
- Accession number :
- 22011407
- Full Text :
- https://doi.org/10.2337/dc11-1409