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Impact of colonoscopic screening in male and female Lynch syndrome carriers with an MSH2 mutation.
- Source :
-
Clinical genetics [Clin Genet] 2012 Nov; Vol. 82 (5), pp. 439-45. Date of Electronic Publication: 2011 Nov 15. - Publication Year :
- 2012
-
Abstract
- The lifetime risk of developing colorectal cancer (CRC) in Lynch syndrome (LS) carriers is very high. To determine the impact of colonoscopic screening in 54 male and 98 female MSH2 mutation carriers, outcomes were compared with 94 males and 76 females who were not screened. CRC incidence and survival in the screened group were compared to that expected, derived from the non-screened group. To correct for survivor bias, controls were matched for age at entry into screening and also for gender. In males, median age to CRC was 58 years, whereas expected was 47 years (p = 0.000), and median survival was 66 years vs 62 years (p = 0.034). In screened females, median age to CRC was 79 years compared to 57 years in the non-screened group (p = 0.000), and median survival was 80 years compared with expected of 63 years (p = 0.001). Twenty percent of males and 7% of females developed an interval CRC within 2 years of previous colonoscopy. Although colonoscopic screening was associated with decreased CRC risk and better survival, CRCs continued to occur. CRC development may be further reduced by decreasing the screening interval to 1 year and improving quality of colonoscopy.<br /> (© 2011 John Wiley & Sons A/S.)
- Subjects :
- Aged
Aged, 80 and over
Colorectal Neoplasms genetics
Data Collection
Female
Follow-Up Studies
Heterozygote
Humans
Incidence
Male
Middle Aged
Colonoscopy methods
Colorectal Neoplasms, Hereditary Nonpolyposis diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis genetics
MutS Homolog 2 Protein genetics
Mutation
Subjects
Details
- Language :
- English
- ISSN :
- 1399-0004
- Volume :
- 82
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Clinical genetics
- Publication Type :
- Academic Journal
- Accession number :
- 22011075
- Full Text :
- https://doi.org/10.1111/j.1399-0004.2011.01802.x