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[Serotonin syndrome in the course of drug-poisoning--case presentation].
- Source :
-
Przeglad lekarski [Przegl Lek] 2011; Vol. 68 (8), pp. 523-6. - Publication Year :
- 2011
-
Abstract
- Unlabelled: Serotonin syndrome is caused by excess serotonin in the central nervous system. It usually occurs as adverse drug-therapy (neuroleptic agents, monoamine oxidase inhibitors, serotonin reuptake inhibitors and others).<br />Case Presentation: a 50-year-old woman with a history of depression, was admitted to our hospital, due to suicidal drug poisoning (moclobemide- 4500 mg, venlafaxine 1050 mg, mianserin 300 mg and cytisine 30mg). She was also drunk. The patient was unconscious and sweaty, on the ECG tachycardia (120/min) was observed. In addition, several hours after admission, the patient developed acute respiratory failure, we observed myoclonus, lockjaw, body temperature increased to 37.3 degrees Celsius, and blood pressure was 170/80 mmHg. During the neurological examination there was a tendency to bilaterall Babinski sign and the nystagmus was present. The patient was intubated, and we started an intravenous infusion of Relanium. In laboratory studies: ethanol: 2.52 g/l, tests for benzodiazepines and tricyclic antidepressants were negative, WBC 13.1 tys/microl, CPK was elevated to 372 U/L, other parameters (electrolytes, transaminases, serum total protein, glucose, CRP, creatinine) were normal. The patient required intensive care and treatment during the next two days. The diagnosis of serotonin syndrome was based on the Hunter's criteria, which are more sensitive and more specific than Sternbach's criteria. The patient was discharged from hospital in good condition.
- Subjects :
- Alcoholic Intoxication complications
Azocines poisoning
Bradycardia chemically induced
Depressive Disorder complications
Depressive Disorder drug therapy
Electrocardiography
Female
Humans
Middle Aged
Myoclonus chemically induced
Quinolizines poisoning
Respiratory Insufficiency chemically induced
Serotonin Syndrome diagnosis
Serotonin Syndrome therapy
Venlafaxine Hydrochloride
Alkaloids poisoning
Cyclohexanols poisoning
Mianserin poisoning
Moclobemide poisoning
Serotonin Syndrome chemically induced
Selective Serotonin Reuptake Inhibitors poisoning
Suicide, Attempted
Subjects
Details
- Language :
- Polish
- ISSN :
- 0033-2240
- Volume :
- 68
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Przeglad lekarski
- Publication Type :
- Academic Journal
- Accession number :
- 22010456