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Survey of anaemia and Helicobacter pylori infection in adolescent girls in Suihua, China and enhancement of iron intervention effects by H. pylori eradication.
- Source :
-
The British journal of nutrition [Br J Nutr] 2012 Jul; Vol. 108 (2), pp. 357-62. Date of Electronic Publication: 2011 Oct 18. - Publication Year :
- 2012
-
Abstract
- In the present study, we investigated the prevalence of anaemia and Fe deficiency anaemia (IDA) and explored the relationship between Helicobacter pylori infection and IDA in adolescent girls. A total of 1037 adolescent girls from Suihua, China were enrolled. Hb, serum ferritin (SF), serum transferrin receptor (sTfR) and serum IgG antibodies to H. pylori were measured. Participants with IDA and co-existing H. pylori infection (n 80) who had an intake of >25 mg/d of Fe were assigned randomly to the intervention and control groups. Patients in the intervention group were administered a 12-week course of oral EDTA-Na-Fe (60 mg Fe/dose, three times a week) and a 2-week course of colloidal bismuth subcitrate, amoxicillin and metronidazole. Subjects in the control group were administered EDTA-Na-Fe alone. Hb, SF and sTfR were reassessed 3 months after the 12-week regimen ended. Prevalence of anaemia, Fe deficiency (defined as SF < 12·0 μg/l), IDA and H. pylori infection in the population of 1037 was 19.5, 40.4, 17.1 and 31.2 %, respectively. The prevalence of H. pylori infection in the IDA group was 46.9 %, while the non-anaemic group had 28.1 % prevalence. A significant increase in Hb and SF and a decrease in sTfR value were found in the intervention group and the H. pylori-negative group. Findings suggest that IDA is still one of the prominent problems in adolescent girls. There is an association between H. pylori infection and IDA. Treatment of H. pylori infection is associated with a more rapid response to oral Fe therapy.
- Subjects :
- Adolescent
Amoxicillin therapeutic use
Anemia, Iron-Deficiency blood
Anemia, Iron-Deficiency complications
Anemia, Iron-Deficiency diet therapy
Anemia, Iron-Deficiency ethnology
Anti-Bacterial Agents therapeutic use
Anti-Ulcer Agents therapeutic use
Antibodies, Bacterial analysis
Child
China epidemiology
Dietary Supplements
Drug Therapy, Combination
Edetic Acid therapeutic use
Female
Ferric Compounds therapeutic use
Follow-Up Studies
Helicobacter Infections complications
Helicobacter Infections drug therapy
Helicobacter Infections microbiology
Humans
Mass Screening
Metronidazole therapeutic use
Organometallic Compounds therapeutic use
Prevalence
Suburban Health ethnology
Urban Health ethnology
Anemia, Iron-Deficiency epidemiology
Helicobacter Infections epidemiology
Helicobacter pylori immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2662
- Volume :
- 108
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The British journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 22004585
- Full Text :
- https://doi.org/10.1017/S0007114511005666