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Subtype and pathway specific responses to anticancer compounds in breast cancer.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Feb 21; Vol. 109 (8), pp. 2724-9. Date of Electronic Publication: 2011 Oct 14. - Publication Year :
- 2012
-
Abstract
- Breast cancers are comprised of molecularly distinct subtypes that may respond differently to pathway-targeted therapies now under development. Collections of breast cancer cell lines mirror many of the molecular subtypes and pathways found in tumors, suggesting that treatment of cell lines with candidate therapeutic compounds can guide identification of associations between molecular subtypes, pathways, and drug response. In a test of 77 therapeutic compounds, nearly all drugs showed differential responses across these cell lines, and approximately one third showed subtype-, pathway-, and/or genomic aberration-specific responses. These observations suggest mechanisms of response and resistance and may inform efforts to develop molecular assays that predict clinical response.
- Subjects :
- Breast Neoplasms genetics
Cell Line, Tumor
Drug Screening Assays, Antitumor
Female
Gene Dosage genetics
Humans
Models, Biological
Signal Transduction genetics
Transcription, Genetic drug effects
Antineoplastic Agents pharmacology
Antineoplastic Agents therapeutic use
Breast Neoplasms classification
Breast Neoplasms drug therapy
Signal Transduction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1091-6490
- Volume :
- 109
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 22003129
- Full Text :
- https://doi.org/10.1073/pnas.1018854108