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EpCAM expression is an indicator of recurrence in basal-like breast cancer.
- Source :
-
Breast cancer research and treatment [Breast Cancer Res Treat] 2012 Jun; Vol. 133 (2), pp. 575-82. Date of Electronic Publication: 2011 Oct 15. - Publication Year :
- 2012
-
Abstract
- Advances in the understanding of the molecular basis of breast cancer have necessitated a definition of more sensitive and specific indicators of prognosis that are central to the underlying cancer biology and that reflect the complicated and heterogeneous nature of the disease. This study investigates the expression of epithelial cell adhesion molecule (EpCAM) in breast cancer particularly basal-like phenotype group which remains unclear. EpCAM expression was assessed using immunohistochemistry in a large well-characterised series of breast carcinomas prepared as tissue microarrays. Relationships between EpCAM expression with molecular subtypes, clinicopathological variables and patients' outcome were examined. EpCAM expression was associated with higher tumour grade (P < 0.001), larger tumour size (P < 0.001) and basal phenotype (P = 0.03). Importantly, within the basal-like tumours those positive for EpCAM showed a significantly shorter DFI (LR = 7.97, P = 0.005) and MFS (LR 4.01, P = 0.045). EpCAM may play a role in breast cancer progression and its expression is associated with poor patient outcome in basal-like breast cancer, independent of other prognostic factors.
- Subjects :
- Adult
Aged
Antigens, Neoplasm genetics
Biomarkers, Tumor metabolism
Breast Neoplasms mortality
Cell Adhesion Molecules genetics
Epithelial Cell Adhesion Molecule
Female
Gene Expression
Humans
Middle Aged
Neoplasm Grading
Neoplasm Recurrence, Local metabolism
Neoplasm Staging
Neoplasms, Basal Cell mortality
Prognosis
Survival Analysis
Antigens, Neoplasm metabolism
Breast Neoplasms diagnosis
Breast Neoplasms metabolism
Cell Adhesion Molecules metabolism
Neoplasm Recurrence, Local diagnosis
Neoplasms, Basal Cell diagnosis
Neoplasms, Basal Cell metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7217
- Volume :
- 133
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Breast cancer research and treatment
- Publication Type :
- Academic Journal
- Accession number :
- 22002520
- Full Text :
- https://doi.org/10.1007/s10549-011-1813-7