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P450(BM3) on steroids: the Swiss Army knife P450 enzyme just gets better.
- Source :
-
Chembiochem : a European journal of chemical biology [Chembiochem] 2011 Nov 25; Vol. 12 (17), pp. 2537-9. Date of Electronic Publication: 2011 Oct 13. - Publication Year :
- 2011
-
Abstract
- The catalytic regio- and stereoselective oxidation of aliphatic C-H bonds by using atmospheric dioxygen as the oxidant is a highly desirable reaction. Reetz and co-workers have recently reported the development of P450(BM3) mutants that oxidise testosterone with greatly increased turnover activity, total stereoselectivity and >95 % regioselectivity.<br /> (Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Bacterial Proteins chemistry
Bacterial Proteins genetics
Biocatalysis
Catalytic Domain
Cytochrome P-450 Enzyme System chemistry
Cytochrome P-450 Enzyme System genetics
Mutation
NADPH-Ferrihemoprotein Reductase chemistry
NADPH-Ferrihemoprotein Reductase genetics
Oxidation-Reduction
Protein Structure, Secondary
Stereoisomerism
Steroids chemistry
Testosterone chemistry
Testosterone metabolism
Bacterial Proteins metabolism
Cytochrome P-450 Enzyme System metabolism
NADPH-Ferrihemoprotein Reductase metabolism
Steroids metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1439-7633
- Volume :
- 12
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Chembiochem : a European journal of chemical biology
- Publication Type :
- Academic Journal
- Accession number :
- 21998091
- Full Text :
- https://doi.org/10.1002/cbic.201100606