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Myocardial toxicity in a group of greyhounds administered ractopamine.
- Source :
-
Veterinary pathology [Vet Pathol] 2012 May; Vol. 49 (3), pp. 569-73. Date of Electronic Publication: 2011 Oct 12. - Publication Year :
- 2012
-
Abstract
- Ractopamine, a synthetic β(2)-adrenoceptor agonist, is widely used as a feed additive in the United States to promote a reduction in body fat and enhance muscle growth in cattle, pigs, and turkeys. It has the potential for illegal use in show and racing animals because it may affect performance via its β-adrenergic agonist properties or anabolic activities. Nine greyhounds were orally administered 1 mg/kg of ractopamine to investigate the ability to detect the drug in urine. Postdosing, 7 of 9 dogs developed cardiac arrhythmias and had elevated troponin levels indicating myocardial damage. One dog necropsied 4 days postdosing had massive myocardial necrosis, mild to focally moderate skeletal muscle necrosis, and widespread segmental arterial mediolysis. A second dog necropsied 17 days postdosing had mild myocardial necrosis and fibrosis. Scattered arteries exhibited segmental medial and perimedial fibromuscular dysplasia. This is the first reported case of arterial, cardiac, and skeletal muscle damage associated with ractopamine.
- Subjects :
- Administration, Oral
Adrenergic beta-Agonists administration & dosage
Adrenergic beta-Agonists urine
Animals
Arrhythmias, Cardiac chemically induced
Dogs
Muscle, Skeletal drug effects
Muscle, Skeletal pathology
Myocardium pathology
Necrosis pathology
Necrosis veterinary
Performance-Enhancing Substances administration & dosage
Performance-Enhancing Substances urine
Phenethylamines administration & dosage
Phenethylamines urine
Substance Abuse Detection methods
Troponin metabolism
Adrenergic beta-Agonists adverse effects
Arrhythmias, Cardiac veterinary
Dog Diseases chemically induced
Performance-Enhancing Substances adverse effects
Phenethylamines adverse effects
Substance Abuse Detection veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1544-2217
- Volume :
- 49
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Veterinary pathology
- Publication Type :
- Academic Journal
- Accession number :
- 21997565
- Full Text :
- https://doi.org/10.1177/0300985811424752