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[Four cases of locally advanced colorectal cancer resected successfully after preoperative chemotherapy].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2011 Oct; Vol. 38 (10), pp. 1699-703. - Publication Year :
- 2011
-
Abstract
- We describe four cases of locally advanced colorectal cancer resected successfully after preoperative chemotherapy conducted between April of 2007 and April of 2009. The average age of the patients was 66.3 years (range, 40-77 years). Because of tumor invasion into the surrounding organs, preoperative chemotherapy with FOLFOX4 was performed. The average number of courses of chemotherapy was 5.2 (range, 4-7). After chemotherapy, we were able to perform radical operations for all four cases. Histopathological examination of the tumor revealed Grade 3 in one case. There were no postoperative complications and no recurrences in any of the cases. We performed curative surgery after chemotherapy, and good results were obtained. Preoperative chemotherapy may be effective for avoiding excessive intervention surgeries such as total pelvic exenteration, preserving bladder and rectal functions, and for maintening QOL.
- Subjects :
- Adult
Aged
Colorectal Neoplasms pathology
Colorectal Neoplasms surgery
Combined Modality Therapy
Fluorouracil therapeutic use
Humans
Leucovorin therapeutic use
Male
Neoplasm Staging
Organoplatinum Compounds therapeutic use
Tomography, X-Ray Computed
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Colorectal Neoplasms drug therapy
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 38
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 21996971