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Procalcitonin serum concentration in lung transplant recipients during mold colonization or infection.
- Source :
-
Transplantation proceedings [Transplant Proc] 2011 Oct; Vol. 43 (8), pp. 3089-91. - Publication Year :
- 2011
-
Abstract
- Background: This publication attempted to evaluate the frequency of mold colonization and infection and the procalcitonin serum concentrations (PCT) among lung transplant recipients.<br />Methods and Materials: We included 49 patients (36 males and 13 females) of mean age at transplantation of 47.1±13.6 years. Molds were isolated using routine microbiologic methods. PCT (ng/mL) was measured using an immunoluminescence assay with values below 0.5 showing no probability of infection, 0.5 to 2.0, a moderate infection risk; 2.0 to 10, a high infection risk; and above 10 high sepsis risk.<br />Results: Twenty-four (49%) patients revealed the presence of molds in material from the lower respiratory tract (sputum, tracheal, or tracheobronchial aspirate), mini-bronchoalveolar lavage. Aspergillus species was isolated in 14 (28.6%) patients, Penicillium in 7 (14.3%) patients, and Zygomycetes fungi in 9 (18.4%) patients. The average PCT value from 61 examinations of PCT during fungal isolation was 0.5±0.7 ng/mL. However, when the studied group was categorized according to the PCT range, the rates for the groups were no infection (n=30; 49.2%), moderate (n=20; 32.8%), high (n=9; 14.8%) and high sepsis risk (n=2; 3.3%).<br />Conclusions: The mold colonization of transplanted lung is a frequent complication and should be considered even in the case of proper prophylaxis. Procalcitonin might be the marker helpful in mold infection diagnosis.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Biomarkers blood
Calcitonin Gene-Related Peptide
Female
Humans
Invasive Pulmonary Aspergillosis blood
Invasive Pulmonary Aspergillosis etiology
Lung Diseases, Fungal microbiology
Lung Transplantation physiology
Male
Middle Aged
Penicillium isolation & purification
Postoperative Complications microbiology
Zygomycosis blood
Zygomycosis etiology
Calcitonin blood
Lung Diseases, Fungal blood
Lung Diseases, Fungal etiology
Lung Transplantation adverse effects
Postoperative Complications blood
Postoperative Complications etiology
Protein Precursors blood
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2623
- Volume :
- 43
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Transplantation proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 21996233
- Full Text :
- https://doi.org/10.1016/j.transproceed.2011.08.057