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Hepatoprotective effect of prolactin and cysteine contained in perfusion and preservation solutions on porcine liver stored in simple hypothermia.
- Source :
-
Transplantation proceedings [Transplant Proc] 2011 Oct; Vol. 43 (8), pp. 2882-6. - Publication Year :
- 2011
-
Abstract
- Introduction: The aim of our study was to determine the results of histidine-tryptophan-ketoglutarate (HTK) solutions modified by the addition of the antioxidant cysteine (Cys), and of prolactin (PRL) on storage of isolated porcine livers.<br />Methods: We measured in the media of isolated livers stored for 24 hours in HTK (control group) or modified HTK+Cys (0.3 mmol/L)+PRL (3 IU/L study group) the amounts of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), lactic acid as well as Ca (II), Mg (II), Na (I) and K (I) ions during a 30-minute perfusion after 24 hours of storage.<br />Results: All tested markers were released more slowly into HTK+Cys+PRL with less release of K(I) and Mg(II) and greater of Na(I) and Ca(II) ions.<br />Conclusions: Addition of the Cys and PRL to HTK positively affected 24-hour storage of isolated livers.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Alanine Transaminase metabolism
Animals
Aspartate Aminotransferases metabolism
Cations metabolism
Cold Ischemia
Female
Glucose chemistry
In Vitro Techniques
L-Lactate Dehydrogenase metabolism
Lactic Acid metabolism
Liver Transplantation
Mannitol chemistry
Organ Preservation Solutions chemistry
Perfusion
Potassium Chloride chemistry
Procaine chemistry
Sus scrofa
Time Factors
Cysteine administration & dosage
Liver drug effects
Liver metabolism
Organ Preservation methods
Prolactin administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2623
- Volume :
- 43
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Transplantation proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 21996179
- Full Text :
- https://doi.org/10.1016/j.transproceed.2011.08.064