Back to Search Start Over

CD69 is independently prognostic in chronic lymphocytic leukemia: a comprehensive clinical and biological profiling study.

Authors :
Del Poeta G
Del Principe MI
Zucchetto A
Luciano F
Buccisano F
Rossi FM
Bruno A
Biagi A
Bulian P
Maurillo L
Neri B
Bomben R
Simotti C
Coletta AM
Dal Bo M
de Fabritiis P
Venditti A
Gattei V
Amadori S
Source :
Haematologica [Haematologica] 2012 Feb; Vol. 97 (2), pp. 279-87. Date of Electronic Publication: 2011 Oct 11.
Publication Year :
2012

Abstract

Background: CD69 is expressed in several hemopoietic cells and is an early activation marker in chronic lymphocytic leukemia. Chronic lymphocytic leukemia is a clinically heterogeneous disease which needs novel prognostic parameters which can be easily and efficiently managed.<br />Design and Methods: We investigated CD69 by flow cytometry in a series of 417 patients affected by chronic lymphocytic leukemia and compared this to other biological and clinical prognosticators.<br />Results: CD69 was associated with Rai stages (P=0.00002), β(2)-microglobulin (P=0.0005) and soluble CD23 (P<0.0001). CD69 and ZAP-70 (P=0.018) or CD38 (P=0.00015) or immunoglobulin variable heavy chain gene mutations (P=0.0005) were also significantly correlated. Clinically, CD69 positive chronic lymphocytic leukemias received chemotherapy more frequently (74%; P<0.0001), and presented a shorter duration of response after fludarabine plus rituximab (P=0.010) as well as shorter progression free survival and overall survival (P<0.0001). CD69 demonstrated true additive prognostic properties, since the CD69(+) plus ZAP-70(+) or CD38(+) or immunoglobulin variable heavy chain gene unmutated patients had the worst progression free survival and overall survival (P<0.0001). Interestingly, low CD69 expression was necessary to correctly prognosticate the longer progression free survival of patients with a low tumor burden of β(2)-microglobulin (P=0.002), of soluble CD23 (P=0.020), or of Rai stages 0-I (P=0.005). CD69 was confirmed to be an independent prognostic factor in multivariate analysis of progression free survival (P=0.017) and overall survival (P=0.039).<br />Conclusions: Our data indicate that CD69 is significantly correlated with poor clinical and biological prognostic factors and is confirmed to be an independent disease prognosticator. This supports its introduction in a routine laboratory assessment and, possibly, in a prognostic scoring system for chronic lymphocytic leukemia, after an adequate standardization process.

Details

Language :
English
ISSN :
1592-8721
Volume :
97
Issue :
2
Database :
MEDLINE
Journal :
Haematologica
Publication Type :
Academic Journal
Accession number :
21993667
Full Text :
https://doi.org/10.3324/haematol.2011.052829