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Idiopathic interstitial lung disease with anti-SSA antibody.
- Source :
-
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2011 Dec; Vol. 50 (12), pp. 2245-50. Date of Electronic Publication: 2011 Oct 08. - Publication Year :
- 2011
-
Abstract
- Objectives: Consensus is lacking on the immunological tests to perform for diagnosis of interstitial lung diseases (ILDs). In particular, the value of detecting anti-SSA antibody in this context is unknown. We aimed to determine whether the detection of anti-SSA antibody in patients with ILD can identify a subgroup of patients with CTD.<br />Methods: We compared the characteristics of patients with newly diagnosed apparently idiopathic ILD with anti-SSA antibody [anti-SSA(+) group] and without anti-SSA antibody (control group). RESULTS; Anti-SSA(+) patients (n = 15) more often had extra-respiratory signs (xerostomia and ocular dryness), auto-immune features, a CT scan pattern of non-specific interstitial pneumonia and more severe lung function alteration than controls (n = 30). Of patients who were anti-SSA(+), 2 met the criteria for SS and 13 (86%) of 15 met the criteria for the diagnosis of undifferentiated CTD.<br />Conclusions: Our results suggest that identification of anti-SSA antibody in patients with early ILD can reveal a specific subgroup of patients with more ground glass opacity and more severe lung function impairment than those without anti-SSA antibody.
- Subjects :
- Aged
Biomarkers analysis
Bronchoalveolar Lavage Fluid cytology
Case-Control Studies
Female
Humans
Immunologic Tests methods
Lung Diseases, Interstitial pathology
Lung Diseases, Interstitial physiopathology
Male
Middle Aged
Respiratory Function Tests
Retrospective Studies
Tomography, X-Ray Computed
Antibodies, Antinuclear analysis
Lung Diseases, Interstitial diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1462-0332
- Volume :
- 50
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Rheumatology (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 21984768
- Full Text :
- https://doi.org/10.1093/rheumatology/ker267