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Intracranial hemorrhage, outcome, and mortality after intra-arterial therapy for acute ischemic stroke in patients under oral anticoagulants.
- Source :
-
Stroke [Stroke] 2011 Nov; Vol. 42 (11), pp. 3061-6. Date of Electronic Publication: 2011 Oct 06. - Publication Year :
- 2011
-
Abstract
- Background and Purpose: Use of intravenous tissue-type plasminogen activator (IV tPA) for acute ischemic stroke is restricted to patients with an international normalized ratio (INR) less than 1.7. However, a recent study showed increased risk of symptomatic intracranial hemorrhage after IV tPA use in patients with oral anticoagulants (OAC) even with an INR less than 1.7. The present study assessed the risk of symptomatic intracranial hemorrhage, clinical outcome, and mortality after intra-arterial therapy (IAT) in patients with and without previous use of OAC.<br />Methods: Consecutive patients treated with IAT from December 1992 to October 2010 were included. Clinical outcome and mortality were assessed 90 days after stroke onset. Patients with and without previous use of OAC were compared.<br />Results: Overall, 714 patients were treated with IAT. Twenty-eight patients (3.9%) were under OAC at time of symptom onset. Median INR in the OAC group was 1.79 (interquartile range [IQR], 1.41-2.3) and 1.01 (IQR, 1.0-1.09; P<0.0001) in the group without OAC. Patients treated with OAC at admission underwent more often mechanical-only IAT than did patients without OAC (46.4% versus 12.8%; P<0.0001). Comparing patients with and without previous use of OAC, we did not find any statistical difference in the rate of symptomatic intracranial hemorrhage (7.1% versus 6.0%; P=0.80), unfavorable outcome (modified Rankin Scale score, 3-6; 67.9% versus 50.9%; P=0.11), and mortality (17.9% versus 21.6%; P=0.58).<br />Conclusions: Previous use of OAC did not significantly increase the risk of symptomatic intracranial hemorrhage after IAT or the risk of unfavorable outcome and mortality 90 days after IAT.
- Subjects :
- Administration, Oral
Aged
Brain Ischemia drug therapy
Cohort Studies
Female
Humans
Infusions, Intra-Arterial
Intracranial Hemorrhages drug therapy
Male
Middle Aged
Retrospective Studies
Stroke drug therapy
Treatment Outcome
Anticoagulants administration & dosage
Brain Ischemia mortality
Intracranial Hemorrhages mortality
Stroke mortality
Thrombolytic Therapy methods
Tissue Plasminogen Activator administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4628
- Volume :
- 42
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Stroke
- Publication Type :
- Academic Journal
- Accession number :
- 21980194
- Full Text :
- https://doi.org/10.1161/STROKEAHA.111.615476