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Multiparametric analysis of magnetic resonance images for glioma grading and patient survival time prediction.
- Source :
-
Acta radiologica (Stockholm, Sweden : 1987) [Acta Radiol] 2011 Nov 01; Vol. 52 (9), pp. 1052-60. Date of Electronic Publication: 2011 Oct 03. - Publication Year :
- 2011
-
Abstract
- Background: A systematic comparison of magnetic resonance imaging (MRI) options for glioma diagnosis is lacking.<br />Purpose: To investigate multiple MR-derived image features with respect to diagnostic accuracy in tumor grading and survival prediction in glioma patients.<br />Material and Methods: T1 pre- and post-contrast, T2 and dynamic susceptibility contrast scans of 74 glioma patients with histologically confirmed grade were acquired. For each patient, a set of statistical features was obtained from the parametric maps derived from the original images, in a region-of-interest encompassing the tumor volume. A forward stepwise selection procedure was used to find the best combinations of features for grade prediction with a cross-validated logistic model and survival time prediction with a cox proportional-hazards regression.<br />Results: Presence/absence of enhancement paired with kurtosis of the FM (first moment of the first-pass curve) was the feature combination that best predicted tumor grade (grade II vs. grade III-IV; median AUC = 0.96), with the main contribution being due to the first of the features. A lower predictive value (median AUC = 0.82) was obtained when grade IV tumors were excluded. Presence/absence of enhancement alone was the best predictor for survival time, and the regression was significant (P < 0.0001).<br />Conclusion: Presence/absence of enhancement, reflecting transendothelial leakage, was the feature with highest predictive value for grade and survival time in glioma patients.
Details
- Language :
- English
- ISSN :
- 1600-0455
- Volume :
- 52
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Acta radiologica (Stockholm, Sweden : 1987)
- Publication Type :
- Academic Journal
- Accession number :
- 21969702
- Full Text :
- https://doi.org/10.1258/ar.2011.100510