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Dendritic cell dysfunction during primary HIV-1 infection.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2011 Nov 15; Vol. 204 (10), pp. 1557-62. Date of Electronic Publication: 2011 Oct 03. - Publication Year :
- 2011
-
Abstract
- Dendritic cells have critical roles for generating and fine-tuning adaptive immune responses and for regulating immune activity through cytokine secretion. In this study, we analyzed functional properties of dendritic cells in primary human immunodeficiency virus type 1 (HIV-1) infection. We found substantial disarray of the functional properties of myeloid and plasmacytoid dendritic cells in acute HIV-1 infection, which included defective antigen-presenting and cytokine secretion properties and was associated with a distinct surface expression profile of immunomodulatory dendritic cell receptors from the leukocyte immunoglobulin-like receptor family. These data indicate that key functional properties of dendritic cells are compromised during primary HIV-1 infection.
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 204
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 21969335
- Full Text :
- https://doi.org/10.1093/infdis/jir616