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Reproductive factors and Parkinson's disease: a multicenter case-control study.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2011 Dec; Vol. 26 (14), pp. 2563-6. Date of Electronic Publication: 2011 Sep 28. - Publication Year :
- 2011
-
Abstract
- Background: The objective of this study was to evaluate the possible association between endogenous and exogenous estrogens and Parkinson's disease (PD).<br />Methods: The FRAGAMP study is a large Italian multicenter case-control study. PD was diagnosed according to Gelb's criteria. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. Adjusted ORs and 95% CIs were estimated using multivariate analysis (logistic regression).<br />Results: Two hundred PD women (mean age, 68.0 ± 9.5 years) and 299 control women (mean age, 61.8 ± 9.9 years) were enrolled in the study. Age at menarche, age at menopause, fertile life duration, cumulative duration of pregnancies, hormone replacement therapy, and surgical menopause were not significantly associated with PD. Multivariate analysis showed a significant positive association between use of oral contraceptives and PD, with an adjusted OR of 3.27 (95% CI, 1.24-8.59; P = .01).<br />Conclusions: Our data suggest that oral contraceptives could increase the risk of PD.<br /> (Copyright © 2011 Movement Disorder Society.)
- Subjects :
- Aged
Case-Control Studies
Female
Humans
Italy epidemiology
Logistic Models
Middle Aged
Multivariate Analysis
Pregnancy
Reproduction physiology
Risk Factors
Surveys and Questionnaires
Contraceptives, Oral, Hormonal therapeutic use
Estrogen Replacement Therapy statistics & numerical data
Estrogens therapeutic use
Leiomyoma epidemiology
Menopause physiology
Parkinson Disease epidemiology
Uterine Neoplasms epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1531-8257
- Volume :
- 26
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 21956541
- Full Text :
- https://doi.org/10.1002/mds.23951