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The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide.
- Source :
-
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2012 Apr; Vol. 61 (4), pp. 469-80. Date of Electronic Publication: 2011 Sep 27. - Publication Year :
- 2012
-
Abstract
- Although lymphomas account for almost half of blood-derived cancers that are diagnosed each year, the causes of new cases are poorly understood, as reflected by the relatively few risk factors established. Galectin-1, an immunoregulatory ß-galactoside-binding protein, has been widely associated with tumor-immune escape. The aim of the present work was to study the relationship between tumor growth rate, aggressiveness, and response to cyclophosphamide (Cy) therapy with regard to Gal-1 expression in murine T-cell lymphoma models. By means of a disruptive selection process for tumor growth rate, we generated two lymphoma variants from a parental T-cell lymphoma, which have unique characteristics in terms of tumor growth rate, spontaneous regression, metastatic capacity, Gal-1 expression and sensitivity to Cy therapy. Here, we show that Gal-1 expression strongly correlates with tumor growth rate, metastatic capacity and response to single-dose Cy therapy in T-cell lymphoma models; this association might have important consequences for evaluating prognosis and treatments of this type of tumors.
- Subjects :
- Animals
CD4 Antigens metabolism
Cell Proliferation drug effects
Cyclophosphamide administration & dosage
Female
Forkhead Transcription Factors metabolism
Galectin 1 genetics
Galectin 1 immunology
Gene Expression Regulation, Neoplastic
Humans
Immunosuppression Therapy
Interleukin-2 Receptor alpha Subunit metabolism
Lymphoma, T-Cell drug therapy
Lymphoma, T-Cell immunology
Mice
Neoplasm Metastasis
T-Lymphocytes, Regulatory drug effects
T-Lymphocytes, Regulatory immunology
T-Lymphocytes, Regulatory pathology
Galectin 1 metabolism
Lymphoma, T-Cell pathology
T-Lymphocytes, Regulatory metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0851
- Volume :
- 61
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer immunology, immunotherapy : CII
- Publication Type :
- Academic Journal
- Accession number :
- 21947259
- Full Text :
- https://doi.org/10.1007/s00262-011-1114-3