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Naïve CD4+ T cells of Peyer's patches produce more IL-6 than those of spleen in response to antigenic stimulation.
- Source :
-
Immunology letters [Immunol Lett] 2011 Dec 30; Vol. 141 (1), pp. 109-15. Date of Electronic Publication: 2011 Sep 12. - Publication Year :
- 2011
-
Abstract
- Peyer's patches (PPs) are potential sites where specific mucosal immune responses and oral tolerance are induced. The unique features of these immune responses are thought to occur in micromilieu and are largely affected by antigen-presenting cells (APCs) such as dendritic cells. In this study, we investigated the cytokine profiles induced by the activation of CD4(+) T cells of PPs. PP cells from TCR transgenic mice secreted greater amounts of IL-5 and IL-6 than spleen cells after antigenic stimulation. IL-5 was mainly produced by PP non-T cells, whereas IL-6 was secreted by PP CD4(+) cells. PPs contained two major populations including naïve and memory/activated CD4(+) cells; both populations secreted IL-6 upon activation. We also found that CD4(+)/CD62L(hi) naïve cells from PPs secreted a greater amount of IL-6 after stimulation than those from the spleen. Furthermore, subtraction and qPCR analyses revealed that PP CD4(+)/CD62L(hi) cells express a greater amount of transcripts of GA-binding protein β subunit 1 than those of the spleen. These results suggest that naïve T cells as well as non-T cells and activated/memory T cells from PPs are distinct from their splenic counterparts and thus cause unique immune responses the in intestine.<br /> (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Antigen-Presenting Cells immunology
Antigens immunology
Dendritic Cells immunology
GA-Binding Protein Transcription Factor metabolism
Immunity, Mucosal immunology
Interleukin-5 analysis
Interleukin-6 analysis
Mice
Mice, Transgenic
Receptors, Antigen, T-Cell immunology
Receptors, Antigen, T-Cell metabolism
Interleukin-5 biosynthesis
Interleukin-6 biosynthesis
Peyer's Patches cytology
Peyer's Patches immunology
Peyer's Patches metabolism
Spleen cytology
Spleen immunology
Spleen metabolism
T-Lymphocytes immunology
T-Lymphocytes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0542
- Volume :
- 141
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Immunology letters
- Publication Type :
- Academic Journal
- Accession number :
- 21944889
- Full Text :
- https://doi.org/10.1016/j.imlet.2011.09.001