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Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes.
- Source :
-
Molecular immunology [Mol Immunol] 2011 Oct; Vol. 49 (1-2), pp. 395-401. Date of Electronic Publication: 2011 Sep 25. - Publication Year :
- 2011
-
Abstract
- Human leukocyte antigens (HLA) are initially classified by serotyping but recently can be re-grouped by their peptide-presentation characteristics into supertypes. Both HLA-A*0301 and HLA-A*1101 are grouped into A3 supertype. Although a number of cross-presented T cell epitopes of HLA-A*0301 and HLA-A*1101 have been identified, the molecular mechanisms of cross-presentation remain elusive. Herein, the structures of HLA-A*0301 with two HIV-derived immunodominant T cell epitopes were solved and their characteristics in comparison with HLA-A*1101 presenting the same peptides were analyzed. The comparable structures of HLA-A*0301 and HLA-A*1101 with subtle differences illustrate the common modes of cross-presented peptides and the strict HLA-restriction of T cell receptor (TCR)-recognition.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Subjects :
- Epitopes, T-Lymphocyte immunology
HLA-A11 Antigen immunology
HLA-A3 Antigen immunology
Human Immunodeficiency Virus Proteins immunology
Humans
Peptides immunology
Protein Conformation
Receptors, Antigen, T-Cell immunology
Antigen Presentation immunology
Cross-Priming immunology
HLA-A11 Antigen chemistry
HLA-A3 Antigen chemistry
Models, Molecular
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9142
- Volume :
- 49
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Molecular immunology
- Publication Type :
- Academic Journal
- Accession number :
- 21943705
- Full Text :
- https://doi.org/10.1016/j.molimm.2011.08.015