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The effect of curcumin in the ectonucleotidases and acetylcholinesterase activities in synaptosomes from the cerebral cortex of cigarette smoke-exposed rats.

Authors :
Jaques JA
Rezer JF
Gonçalves JF
Spanevello RM
Gutierres JM
Pimentel VC
Thomé GR
Morsch VM
Schetinger MR
Leal DB
Source :
Cell biochemistry and function [Cell Biochem Funct] 2011 Dec; Vol. 29 (8), pp. 703-7. Date of Electronic Publication: 2011 Sep 19.
Publication Year :
2011

Abstract

With the evidence that curcumin may be a potent neuroprotective agent and that cigarette smoke is associated with a decline in the cognitive performance as our bases, we investigated the activities of Ecto-Nucleoside Triphosphate Diphosphohydrolase (NTPDase), 5'-nucleotidase and acetylcholinesterase (AChE) in cerebral cortex synaptosomes from cigarette smoke-exposed rats treated with curcumin (Cur). The experimental procedures entailed two sets of experiments. In the first set, the groups were vehicle, Cur 12·5, 25 and 50 mg·kg(-1) ; those in the second set were vehicle, smoke, smoke and Cur 12·5, 25 and 50 mg·kg(-1) . Curcumin prevented the increased NTPDase, 5'-nucleotidase and AChE activities caused by smoke exposure. We suggest that treatment with Cur was protective because the decrease of ATP and acetylcholine (ACh) concentrations is responsible for cognitive impairment, and both ATP and ACh have key roles in neurotransmission.<br /> (Copyright © 2011 John Wiley & Sons, Ltd.)

Details

Language :
English
ISSN :
1099-0844
Volume :
29
Issue :
8
Database :
MEDLINE
Journal :
Cell biochemistry and function
Publication Type :
Academic Journal
Accession number :
21932293
Full Text :
https://doi.org/10.1002/cbf.1804