Back to Search
Start Over
The effect of curcumin in the ectonucleotidases and acetylcholinesterase activities in synaptosomes from the cerebral cortex of cigarette smoke-exposed rats.
- Source :
-
Cell biochemistry and function [Cell Biochem Funct] 2011 Dec; Vol. 29 (8), pp. 703-7. Date of Electronic Publication: 2011 Sep 19. - Publication Year :
- 2011
-
Abstract
- With the evidence that curcumin may be a potent neuroprotective agent and that cigarette smoke is associated with a decline in the cognitive performance as our bases, we investigated the activities of Ecto-Nucleoside Triphosphate Diphosphohydrolase (NTPDase), 5'-nucleotidase and acetylcholinesterase (AChE) in cerebral cortex synaptosomes from cigarette smoke-exposed rats treated with curcumin (Cur). The experimental procedures entailed two sets of experiments. In the first set, the groups were vehicle, Cur 12·5, 25 and 50 mg·kg(-1) ; those in the second set were vehicle, smoke, smoke and Cur 12·5, 25 and 50 mg·kg(-1) . Curcumin prevented the increased NTPDase, 5'-nucleotidase and AChE activities caused by smoke exposure. We suggest that treatment with Cur was protective because the decrease of ATP and acetylcholine (ACh) concentrations is responsible for cognitive impairment, and both ATP and ACh have key roles in neurotransmission.<br /> (Copyright © 2011 John Wiley & Sons, Ltd.)
- Subjects :
- Adenosine Triphosphatases antagonists & inhibitors
Animals
Cerebral Cortex drug effects
Enzyme Inhibitors administration & dosage
Humans
Male
Nucleotidases antagonists & inhibitors
Nucleotidases metabolism
Rats
Rats, Wistar
Synaptosomes drug effects
Tobacco Smoke Pollution adverse effects
Acetylcholinesterase metabolism
Adenosine Triphosphatases metabolism
Cerebral Cortex enzymology
Curcumin administration & dosage
Environmental Exposure adverse effects
Smoke adverse effects
Synaptosomes enzymology
Nicotiana adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1099-0844
- Volume :
- 29
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cell biochemistry and function
- Publication Type :
- Academic Journal
- Accession number :
- 21932293
- Full Text :
- https://doi.org/10.1002/cbf.1804