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Beyond the joints: neurological involvement in rheumatoid arthritis.
- Source :
-
Clinical rheumatology [Clin Rheumatol] 2012 Jan; Vol. 31 (1), pp. 1-12. Date of Electronic Publication: 2011 Sep 20. - Publication Year :
- 2012
-
Abstract
- Although arthritis is the most notable component, rheumatoid arthritis (RA) is a systemic inflammatory disorder where extra-articular manifestations are common; among them, central and peripheral nervous system involvement is frequent and associated with significant morbidity and, in some cases, reduced life span. It may produce a myriad of symptoms and signs ranging from subtle numbness in a hand, to quadriparesis and sudden death. Central and peripheral neurologic manifestations may arise from structural damage produced by RA in diarthroidal joints, by the systemic inflammatory process of the disease itself or by the drugs used to treat it. Neurologic syndromes may appear suddenly or developed slowly through months, and emerge early or after years of having RA. Neurologic manifestations may be easily overlooked or incorrectly assigned to peripheral arthritis unless the attending physician is aware of these complications. In this article, we review neurologic involvement in RA patients with emphasis on clinical approach for early detection.
- Subjects :
- Antirheumatic Agents adverse effects
Arthritis, Rheumatoid diagnosis
Arthritis, Rheumatoid drug therapy
Autonomic Nervous System Diseases diagnosis
Central Nervous System Diseases diagnosis
Central Nervous System Diseases etiology
Comorbidity
Early Diagnosis
Humans
Peripheral Nervous System Diseases diagnosis
Peripheral Nervous System Diseases etiology
Arthritis, Rheumatoid epidemiology
Autonomic Nervous System Diseases epidemiology
Central Nervous System Diseases epidemiology
Peripheral Nervous System Diseases epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1434-9949
- Volume :
- 31
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 21932019
- Full Text :
- https://doi.org/10.1007/s10067-011-1841-z