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Effects of traditional Chinese medicine on bone remodeling during orthodontic tooth movement.
- Source :
-
Journal of ethnopharmacology [J Ethnopharmacol] 2012 Jun 01; Vol. 141 (2), pp. 642-6. Date of Electronic Publication: 2011 Sep 10. - Publication Year :
- 2012
-
Abstract
- Ethnopharmacological Relevance: Dipsacus asper Wall (Dipsacaceae), Salvia miltiorrhiza (Salvia) and Drynaria fortunei (Drynaria) have been traditionally used in Chinese medicine as the main ingredient of many formulations for the treatment of cardiovascular and inflammatory diseases.<br />Aim of the Study: This study was aimed to evaluate the effect of the traditional Chinese medicine (TCM) Dipsacaceae, Salvia and Drynaria on bone remodeling during orthodontic tooth movement (OTM).<br />Setting: This study was conducted in School of Stomatology, Shandong University between 2009 and 2010 [Jinan, Shandong, China].<br />Materials and Methods: Ninety-six eight-week-old female SPF Wistar rats 180-200 g were selected and randomly divided into four groups of 24: Dipsacaceae group, Salvia group, Drynaria group and control group. Animal models for orthodontic tooth movement were then established which consisted of a closed coil spring ligated to the upper first molar and incisors, exerting a force of 40 g during the experimental period. Rats in the TCM groups were given Dipsacaceae, Salvia and Drynaria decoction respectively by intragastric administration 6 g/kg/day and the control group were given normal saline 3 ml. The rats were sacrificed in batch on the 7th, 14th, 21st and 28th days after orthodontic treatment. Slices from periodontium of the upper first molar were observed under optical microscope. Neovascularization, new bone formation and osteoclast number were observed.<br />Results: The upper first molars were drawn mesial by the force. Telangiectasia and new bone formation in periodontal tissue were significantly in the TCM groups compared with the control group. Application of orthodontic forces in the experimental teeth showed a significant increase (P<0.05) of osteoclast number in the TCM group when compared with the control group. In addition, the number of osteoclast had no significant differences among the TCM groups (P>0.05). Osteoclast number in the TCM group and the control group were 10.12±0.058, 10.13±0.022, 10.09±0.047 and 9.55±0.045, respectively.<br />Conclusions: These findings suggest that the TCM decoction are beneficial to the alveolar bone remodeling by promoting osteoclast differentiation during OTM.<br /> (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Alveolar Process blood supply
Alveolar Process metabolism
Alveolar Process pathology
Animals
Cell Differentiation drug effects
Female
Medicine, Chinese Traditional
Neovascularization, Physiologic drug effects
Orthodontic Wires
Osteoclasts metabolism
Osteoclasts pathology
Plants, Medicinal
Rats
Rats, Wistar
Stress, Mechanical
Time Factors
Alveolar Process drug effects
Bone Remodeling drug effects
Dipsacaceae
Drugs, Chinese Herbal pharmacology
Osteoclasts drug effects
Polypodiaceae
Salvia
Tooth Movement Techniques instrumentation
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7573
- Volume :
- 141
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 21925257
- Full Text :
- https://doi.org/10.1016/j.jep.2011.09.003