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Ras trafficking, localization and compartmentalized signalling.
- Source :
-
Seminars in cell & developmental biology [Semin Cell Dev Biol] 2012 Apr; Vol. 23 (2), pp. 145-53. Date of Electronic Publication: 2011 Sep 08. - Publication Year :
- 2012
-
Abstract
- Ras proteins are proto-oncogenes that are frequently mutated in human cancers. Three closely related isoforms, HRAS, KRAS and NRAS, are expressed in all cells and have overlapping but distinctive functions. Recent work has revealed how differences between the Ras isoforms in their trafficking, localization and protein-membrane orientation enable signalling specificity to be determined. We review the various strategies used to characterize compartmentalized Ras localization and signalling. Localization is an important contextual modifier of signalling networks and insights from the Ras system are of widespread relevance for researchers interested in signalling initiated from membranes.<br /> (Copyright © 2011. Published by Elsevier Ltd.)
- Subjects :
- Amino Acid Sequence
Animals
Cell Membrane chemistry
Endoplasmic Reticulum
Endosomes chemistry
Enzyme Activation
Evolution, Molecular
Golgi Apparatus chemistry
Humans
Molecular Sequence Data
Protein Isoforms chemistry
Protein Isoforms genetics
Protein Structure, Tertiary
Protein Transport
ras Proteins genetics
Cell Compartmentation
Signal Transduction
ras Proteins chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1096-3634
- Volume :
- 23
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Seminars in cell & developmental biology
- Publication Type :
- Academic Journal
- Accession number :
- 21924373
- Full Text :
- https://doi.org/10.1016/j.semcdb.2011.09.002