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Pharmacological conversion of recent atrial fibrillation: a randomized, placebo-controlled study of three antiarrhythmic drugs.
- Source :
-
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology [Anadolu Kardiyol Derg] 2011 Nov; Vol. 11 (7), pp. 600-6. Date of Electronic Publication: 2011 Sep 12. - Publication Year :
- 2011
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Abstract
- Objective: In this study, we randomly compared single oral doses of flecainide, amiodarone and propafenone versus placebo for the conversion of recent atrial fibrillation (AF) (within 48 hours).<br />Methods: This is a randomized prospective, placebo-controlled single-blind study that included 160 consecutive patients with recent AF who were randomly assigned to single oral doses of flecainide (3 mg/kg of weight, n=40), amiodarone (30 mg/kg weight, n=40), propafenone (8.5 mg/kg of weight, n=40) or placebo (n=40). The primary end-point was conversion rate at 24 hours after the drug intake. The association between antiarrhythmic use and conversion rate was tested with multiple logistic regressions.<br />Results: The primary end-point was achieved in 87.5% of patients with flecainide, 85% of patients with amiodarone, 85% of patients with propafenone and 17.5% of patients with placebo (p<0.001 compared with placebo for all 3 drugs). Conversion rate within 3 hours after drug intake was greater with propafenone (57.5%) or flecainide (45%) compared with amiodarone (0%) or placebo (10%). Between 6 and 24 hours, significantly more patients were converted to sinus rhythm with amiodarone than with flecainide or propafenone. The use of antiarrhythmic drugs was a significant predictor of conversion to sinus rhythm compared to placebo (adjusted OR=19.53, 95% CI 3.14-121.55, p<0.001). No serious side effect occurred.<br />Conclusion: In patients with recent-onset AF, oral flecainide, amiodarone or propafenone are superior to placebo in restoring sinus rhythm within the 24-hour period following the drug intake.
- Subjects :
- Administration, Oral
Amiodarone administration & dosage
Atrial Fibrillation blood
Electrocardiography
Female
Flecainide administration & dosage
Humans
Male
Middle Aged
Propafenone administration & dosage
Prospective Studies
Single-Blind Method
Treatment Outcome
Anti-Arrhythmia Agents administration & dosage
Atrial Fibrillation drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1308-0032
- Volume :
- 11
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 21911317
- Full Text :
- https://doi.org/10.5152/akd.2011.162