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Allopurinol reduces the lethality associated with acute renal failure induced by Crotalus durissus terrificus snake venom: comparison with probenecid.
- Source :
-
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2011 Sep; Vol. 5 (9), pp. e1312. Date of Electronic Publication: 2011 Sep 06. - Publication Year :
- 2011
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Abstract
- Background: Acute renal failure is one of the most serious complications of envenoming resulting from Crotalus durissus terrificus bites. This study evaluated the relevance of hyperuricemia and oxidative stress and the effects of allopurinol and probenecid in renal dysfunction caused by direct nephrotoxicity of C. d. terrificus venom.<br />Methodology/principal Findings: Hematocrit, protein, renal function and redox status were assessed in mice. High ratio of oxidized/reduced glutathione and hyperuricemia induced by C. d. terrificus venom were ameliorated by both, allopurinol or probenecid, but only allopurinol significantly reduced the lethality caused by C. d. terrificus venom. The effectiveness of probenecid is compromised probably because it promoted hypercreatinemia and hypocreatinuria and worsed the urinary hypo-osmolality in envenomed mice. In turn, the highest effectiveness of allopurinol might be due to its ability to diminish the intracellular formation of uric acid.<br />Conclusions/significance: Data provide consistent evidences linking uric acid with the acute renal failure induced by C. d. terrificus venom, as well as that this envenoming in mice constitutes an attractive animal model suitable for studying the hyperuricemia and that the allopurinol deserves to be clinically evaluated as an approach complementary to anti-snake venom serotherapy.
- Subjects :
- Acute Kidney Injury mortality
Animals
Crotalus
Male
Mice
Snake Bites complications
Survival Analysis
Acute Kidney Injury prevention & control
Allopurinol administration & dosage
Antimetabolites administration & dosage
Probenecid administration & dosage
Snake Bites drug therapy
Snake Venoms toxicity
Uricosuric Agents administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1935-2735
- Volume :
- 5
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- PLoS neglected tropical diseases
- Publication Type :
- Academic Journal
- Accession number :
- 21909449
- Full Text :
- https://doi.org/10.1371/journal.pntd.0001312