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Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.
- Source :
-
Nature genetics [Nat Genet] 2011 Sep 11; Vol. 43 (10), pp. 940-7. Date of Electronic Publication: 2011 Sep 11. - Publication Year :
- 2011
-
Abstract
- Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions associated with the presence of carotid plaque (P < 5 × 10(-8)). The associated SNPs mapped in or near genes related to cellular signaling, lipid metabolism and blood pressure homeostasis, and two of the regions were associated with coronary artery disease (P < 0.006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events.
- Subjects :
- Adult
Aged
Aging genetics
Atherosclerosis physiopathology
Cohort Studies
Genetic Loci
Genetic Predisposition to Disease
Genome, Human
Genome-Wide Association Study
Genotype
Heart physiopathology
Humans
Middle Aged
Phenotype
Plaque, Atherosclerotic pathology
Polymorphism, Single Nucleotide
Risk Factors
White People genetics
Atherosclerosis genetics
Carotid Intima-Media Thickness
Coronary Artery Disease genetics
Plaque, Atherosclerotic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 43
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 21909108
- Full Text :
- https://doi.org/10.1038/ng.920