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Steatosis degree, measured by morphometry, is linked to other liver lesions and metabolic syndrome components in patients with NAFLD.
- Source :
-
European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2011 Nov; Vol. 23 (11), pp. 974-81. - Publication Year :
- 2011
-
Abstract
- Background and Aim: We carried out morphometric measurements of steatosis to evaluate relationships between steatosis degree and other liver lesions or metabolic syndrome components in nonalcoholic fatty liver disease (NAFLD).<br />Patients and Methods: We developed an algorithm to measure steatosis area. Two hundred and fourteen patients with NAFLD were included in derivation (10) and validation (204) groups. Controls consisted of patients who were steatosis-free (12), patients with chronic hepatitis C (188), and patients with alcoholic chronic liver disease (94).<br />Results: Accuracy of steatosis area was considered as good or very good in at least 72% of cases by three pathologists. Steatosis areas were as follows: NAFLD = 10.3 ± 9.7%, virus = 2.4 ± 3.1%, alcohol = 7.8 ± 8.2% (P<0.0001). Steatosis area was closely related to steatosis grades in NAFLD (P<0.0001 for linear trend). Steatosis area increased from the fibrosis stage F0 to the fibrosis state F2, then decreased in the stages F3 and F4 (cirrhosis) (P<0.0001 for quadratic trend). Fibrosis was present in an average steatosis area of approximately 4% (defining significant steatosis) and in nonalcoholic steatohepatitis by approximately 8% (defining severe steatosis). Steatosis and fibrosis area increased symmetrically until approximately 10%, then steatosis area decreased to null as average fibrosis area reached 32%. Average fasting glycemia (approximately 92 mg/dl) or triglycerides and BMI plateaued before a steatosis area of approximately 4%, then increased thereafter. Significant steatosis was present in 61.3% of NAFLD versus 20.2% of viral hepatitis (P<0.0001) and in 58.7% of alcoholic liver diseases (P=0.674).<br />Conclusions: The average threshold of steatosis area is 4% for the development of fibrosis or metabolic syndrome components and 8% for nonalcoholic steatohepatitis. Steatosis area may contribute to defining the normal range and clinical course of metabolic components.
- Subjects :
- Adult
Algorithms
Biopsy, Needle
Epidemiologic Methods
Fatty Liver etiology
Female
Hepatitis, Viral, Human complications
Hepatitis, Viral, Human pathology
Humans
Image Interpretation, Computer-Assisted methods
Liver Cirrhosis etiology
Liver Cirrhosis pathology
Liver Diseases, Alcoholic pathology
Male
Middle Aged
Non-alcoholic Fatty Liver Disease
Fatty Liver pathology
Liver pathology
Metabolic Syndrome complications
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5687
- Volume :
- 23
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- European journal of gastroenterology & hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 21904208
- Full Text :
- https://doi.org/10.1097/MEG.0b013e32834a4d82