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Guidance of pharmacotherapy in a complex psychiatric case by CYP450 DNA typing.
- Source :
-
Journal of the American Academy of Nurse Practitioners [J Am Acad Nurse Pract] 2011 Sep; Vol. 23 (9), pp. 459-63. Date of Electronic Publication: 2011 Jul 25. - Publication Year :
- 2011
-
Abstract
- Purpose: To illustrate the utility of CYP450 genotyping to guide clinical psychopharmacological treatment decisions and minimize or avoid harmful and costly adverse drug reactions (ADRs).<br />Data Sources: DNA was extracted from a whole blood sample from the case study subject and tested for CYP450 gene polymorphisms in the CLIA certified Laboratory of Personalized Health at Genomas, Inc. Clinical data were obtained from patient records and clinician observations.<br />Conclusions: We present a case in which the ascertainment of multiple CYP450 isoenzyme deficiencies resulted in a dramatic change in psychotropic treatment approach. Shortly after making these adjustments, the patient saw a significant improvement in most of her debilitating psychiatric symptoms.<br />Implications for Practice: In complex cases, CYP450 DNA testing can guide pharmacotherapy by exposing innate hepatic metabolic deficiencies as a result of DNA polymorphism. In such cases, clinicians can favor treatments that target functional isoenzyme pathways rather than deficient or null pathways thus leading to decreased risk of ADRs and improved patient response.<br /> (©2011 The Author(s) Journal compilation ©2011 American Academy of Nurse Practitioners.)
- Subjects :
- Adult
DNA Fingerprinting instrumentation
Depression genetics
Drug-Related Side Effects and Adverse Reactions prevention & control
Female
Humans
Polymorphism, Genetic genetics
Psychotropic Drugs therapeutic use
Cytochrome P-450 Enzyme System genetics
DNA Fingerprinting methods
Depression drug therapy
Drug Therapy methods
Pharmacogenetics
Psychotropic Drugs adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1745-7599
- Volume :
- 23
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of the American Academy of Nurse Practitioners
- Publication Type :
- Academic Journal
- Accession number :
- 21899640
- Full Text :
- https://doi.org/10.1111/j.1745-7599.2011.00640.x