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Persistent pigmented purpuric dermatitis: granulomatous variant.

Authors :
Macquarrie EK
Pasternak S
Torok M
Veerassamy S
Walsh NM
Source :
Journal of cutaneous pathology [J Cutan Pathol] 2011 Dec; Vol. 38 (12), pp. 979-83. Date of Electronic Publication: 2011 Sep 07.
Publication Year :
2011

Abstract

The persistent pigmented purpuric dermatitides (PPPD) are a spectrum of dermatologic disorders characterized by petechial and pigmented macules usually confined to the lower limbs. Their etiology is unknown and several clinical variants are recognized. At the microscopic level they are characterized by angiocentric lymphocytic inflammation, red blood cell extravasation and hemosiderin deposition. A granulomatous variant of the PPPD has recently been described and to date eleven cases have been reported in the literature. In contrast to the conventional type, this variant is characterized histopathologically by ill-defined, non-necrotizing granulomata admixed with the lymphocytic inflammatory background. Although initially the granulomatous variant of the PPPD was thought to occur only in Asian patients, this sole racial predilection has not been substantiated. A tenuous association with hyperlipidemia has been noted but this requires further study. The principal importance of recognizing this entity lies in the need to include it in the histopathological differential diagnosis of granulomatous dermal infiltrates. We report here an additional patient with the granulomatous variant of PPPD and elaborate on this entity in the context of existing information in the literature.<br /> (Copyright © 2011 John Wiley & Sons A/S.)

Details

Language :
English
ISSN :
1600-0560
Volume :
38
Issue :
12
Database :
MEDLINE
Journal :
Journal of cutaneous pathology
Publication Type :
Academic Journal
Accession number :
21899591
Full Text :
https://doi.org/10.1111/j.1600-0560.2011.01793.x